Spravato® Treatment for Depression
FDA-Approved Relief For Treatment-Resistant Depression - Covered By Insurance
At Serenity Infuse, we provide Spravato® (esketamine) nasal spray — an innovative, FDA-approved treatment designed for adults living with treatment-resistant depression (TRD). If traditional antidepressants haven’t delivered the relief you deserve, Spravato offers a new, evidence-based path toward healing — and it’s covered by most major insurance plans.
What Is Spravato?
Spravato® (esketamine) is the first FDA-approved nasal spray medication specifically designed to treat adults with depression that hasn’t responded to at least two prior antidepressants. Spravato is a prescription-only medication and is administered under medical supervision in a certified clinic like ours.
Unlike traditional antidepressants that target serotonin or dopamine, Spravato works on the NMDA receptor, influencing glutamate — a different neurotransmitter pathway believed to play a role in depression. This novel mechanism may result in rapid symptom relief, often within hours or days of treatment.
Who Is Spravato For?
Spravato may be right for you if you:
Have been diagnosed with major depressive disorder (MDD)
Have not responded adequately to at least two antidepressant medications
Are not pregnant, breastfeeding, or have certain medical conditions (our team will evaluate your eligibility)
Are under the care of a licensed mental health provider
Spravato is not a first-line treatment for depression — it’s used when other medications haven’t worked.
What to Expect During Treatment
INITIAL EVALUATION:
You’ll begin with a comprehensive consultation with one of our experienced psychiatric providers to determine if Spravato is appropriate for you. We’ll also discuss your medical history, current medications, and treatment goals.
IN-CLINIC ADMINISTRATION:
If approved, your Spravato treatment will follow this structure:
- Nasal spray self-administered under clinical supervision
- Two hours of monitoring in a private, calming treatment room
- Vital signs, mood, and side effects are carefully observed throughout
- Transportation requirement: You cannot drive after treatment and must arrange for a ride, rideshare, taxi, or public transit
Sessions are typically twice a week for the first month, followed by a tapering schedule based on your response.
Benefits of Spravato
Rapid relief for some patients within hours or days
Breakthrough mechanism for patients who haven’t responded to oral antidepressants
Supervised, structured care to maximize safety and comfort
FDA-approved and covered by many insurance plans (we can help with verification)
Side Effects and Safety
Common side effects may include:
- Dizziness
- Sedation or fatigue
- Nausea
- Feelings of dissociation (feeling disconnected from reality)
- Elevated blood pressure during treatment
Our team will monitor you closely during every visit to ensure your safety and adjust your treatment as needed.
Insurance & Cost
Spravato is covered by most major insurance plans, but pre-authorization is typically required. Our staff will work with your insurance provider to confirm coverage and help manage paperwork and prior approvals. We also offer self-pay options and financing assistance if needed.
Why Choose Serenity Infuse for Spravato?
We are a certified Spravato treatment center and adhere strictly to REMS (Risk Evaluation and Mitigation Strategy) safety protocols.
At Serenity Infuse, you’ll receive:
Care from board-certified providers experienced in depression and ketamine-based therapies
A private, supportive, and welcoming treatment environment
Ongoing coordination with your primary psychiatrist or therapist
Personalized treatment plans based on your unique needs and goals
Ready to Take the Next Step?
If you’ve struggled to find relief from depression, you are not alone — and effective help is available.
Break the cycle of depression. Rediscover hope.
WE’RE HERE TO HELP.